Echofon for Mac is no longer in development. TUAW's Twitter Client Project surveys popular desktop alternatives in highly subjective reviews.
Hibari (US$9.99) offers a clean, visually pleasing Twitter interface. Unfortunately, as these things go (and despite its price tag), it's not feature complete compared to other clients currently on the market.
You cannot yet load saved searches from the Twitter API, one of the most essential bits of functionality I rely on. The support page notes, "Currently, we do not sync your Hibari searches with your saved searches on Twitter.com." You cannot tweet pictures directly, as I found to my dismay.
The devel
