At randomisation, participants are assigned to either the control arm or the research arm using a 1: Figure 1 Trial Schema. During Phase II of the study, the trial will assess toxicity unexpected and expectedactivity and feasibility in 90 patients in AST Advantage! 466 experimental arm. Activity will be measured as treatment failure-free rate and feasibility as the number of protocol dose modifications and delays. If toxicity, activity and feasibility are found to be unacceptable recruitment into the trial will[…]
