Calorically restricted rodents also show reduced levels of both activated Ras-GTP and activated ERK[ 66, 68 ] suggesting that signal transduction downstream of Ras is also impaired upon caloric restriction but whether these changes in Ras signal transduction contribute to lifespan extension remains to be determined. Moreover, the Ras-responsive transcription factor, AOP, was required Aopen AOP-320 Network lifespan extension by chico mutation [ Aopen AOP-320 Network ]. During growth, such an interaction is required for maximal PI3K activation [ 72[…]
