Epson published on its website a dedicated page about Leopard compatibility of all Epson peripherals with the soon to be released Mac OS X 10.6 Leopard. If for most recent models drivers will already be included in Leopard drivers set, drivers for older models will be available online from "Drivers and Downloads" section of the "Support" site as they become available.
Additional information: http://esupport.epson-europe.com
[translation by Linathael]
