I do a fair amount of presentations, and I have to say Keynote has made my life in front of the big screen a lot easier. Of course, a good remote is really a near necessity when doing presentations, and after trying many of the years I've settled on the Keyspan PR-Pro3 Remote.
It is very Mac friendly, and requires no software at all. You plug in the included receiver in any USB port on your laptop, and turn on the remote. They instantly pair, and you are ready to go. The remote gives you forward and backward controls that work with Keynote or Powerpoint and a button to blank the screen at any time. You also get a 2 button wireless mouse, you can be up to 100 fee