Anime Studio is a really popular animation system for illustrators and animators, and there's good news about the app for Mac users: Anime Studio 9 has now arrived on our platform, in both pro and debut versions. You can see the full comparison of pro and debut features over here, but both versions offer a really impressive Bone Rigging system that allows animators to simply create a skeleton and then pose it for different frames. Other features include an animation timeline and even an included physics engine to help artists make quick and easy physics-based animations.
You can also work with audio right inside the app and there's a whole set of vector drawing features for artists to use as well