Apple has released OS X Mountain Lion 10.8.1, and the update is now available in the Mac App Store under the Updates tab. A manual installer is also available for download.
In the support notes about the update, Apple recommends backing up your system before running the installer. A reboot is required in order to complete the update.
The update includes a number of fixes:
Resolve an issue that may cause Migration Assistant to unexpectedly quit
Improve compatibility when connecting to a Microsoft Exchange server in Mail
Address an issue playing audio through a Thunderbolt display
Resolve an issue that could pre