Textco BioSoftware has released an upgrade of its DNA plasmid mapping software, Gene Construction Kit 3.5. The tool lets researchers manipulate DNA sequences, either graphically or as sequence text. It identifies open reading frames, keeps track of sticky ends during cutting and pasting of restriction enzyme digestion fragments, and assists PCR primer designing. Multiple files can be open and displayed simultaneously, so DNA sequences can be copied and pasted between plasmids and vectors to represent real-world DNA cloning protocols.