For capturing screencasts, one of the more widely-used tools is Camtasia from TechSmith. After many years as a Windows-only application, the company brought Camtasia to the Mac world in 2009, and it's been well-received by Mac users ever since.
TechSmith recently added Camtasia to the Mac App Store to test the waters, which they found welcoming. The app was listed for a while as a "staff favorite," and the company is reporting that sales of Camtasia have risen over 20% since the app appeared in the Mac App Store. TechSmith kept the price at US$99.99 and it's still available directly from the company's website