There are several bloggers here at TUAW who are slowly moving toward a paperless office. Steve Sande has had the best success, sharing some of what he's learned about culling out the piles of paper in his freelance business.
However, it doesn't stop reams of paper from entering your life, or to even begin to manage it. Paperless from Mariner Software, formerly known as ReceiptWallet, aims to pull all of the paper pieces of your digital life into one location, then encourages you to keep going by adding to it by creating separate databases within the program to sort out different parts of your life -- a digital file cabinet, so to speak. Paperless