Aspyr Media has updated the Mac version of Civilization 5 to fix a few bugs and include support for all of the various DLC packs. The downloadable content includes various new civilizations to play with, plus map packs that load up certain areas or scenarios to rule and conquer as your favorite civ.
Unfortunately, the game isn't in the Mac App Store, but it's available at the usual places to buy Mac games online, including Steam. As you'll know if you've ever played any version of Civ, it's a terrific game, and it's good to see that the Mac version has capability for all the DLC now