It's unclear exactly what's going on at the moment, but it appears that the PlayStation Network is down and causing a whole host of related problems for PS3 systems, including 8001050F error codes, game crashes, corrupted trophy info, and even the complete inability to launch certain titles. There's no ETA on when things will get back to normal -- looks like it's gonna be a Blu-ray kind of evening for PS3 owners out there.
[Thanks to everyone who sent this in]PlayStation Network down